STREPTOMYCIN 1 gr

Streptomycin (OSD)

FOR INTRAMUSCULAR USE

 

Per vial: Streptomycin (OSD) (sulfate) 1 gr

Per ampoule of solvent: Water for Injection   3 ml

 

Streptomycin is a bactericidal antibiotic that is well absorbed after intramuscular administration with appreciable concentrations in all organ fluids and tissues except the brain. Streptomycin is detectable in significant amounts in pleural fluid and tuberculous cavities. It is excreted rapidly in the urine by glomerular filtration and decreases in cases of renal insufficiency causing a concurrent rise in serum and tissue levels.

 

Streptomycin is indicated for all forms of tuberculosis (in conjunction with other tuberculostatics). Other infections caused by susceptible strains of microorganisms: Brucellosis, plague, Streptococcus viridans, Enterococcus faecalis in endocardial infections (in combination with penicillin), urinary tract infections, gonorrhoea. It is an effective treatment via the oral route in the treatment of diarrhoea and enteritis, as well as for the reduction of the intestinal flora prior to surgery.

 

Adults: The recommended dose is 1 gram daily, which can be administered in 2 divided doses every 12 hours. 

Chilldren: The recommended dose is 0.5 grams daily, which can be administered in 2 divided doses every 12 hours. In children the dosage can be adjusted at the rate of 20 to 40 mg/kg of body weight daily in 2 to 4 divided doses every 6 - 12 hours.

 

 

Streptomycin Sulfate is usually administered intramuscularly. Administration via intrathecal route may be indicated in the treatment of meningitis caused by sensitive bacteria. The daily dose is usually 25 mg or 50 mg every other day, not exceeding 1 mg per kg of body weight. The injected dose should be dissolved in 10 ml of water for injection or the cerebrospinal fluid of the patient. In any case, the volume of spinal fluid withdrawn should be slightly higher that that of the injection and it should be done slowly. Administered via the oral route, the contents of the bottle can be dissolved in sterile water and administered in 2 to 3 divided doses.

 

Streptomycin is contraindicated in patients with a prior history of hypersensitivity or serious toxic reaction to streptomycin.

 

Cochlear and vestibular function should be monitored in patients on prolonged treatment. It is recommend that those who use this product take the necessary precautions so as to avoid possible cutaneous hypersensitive reactions to streptomycin.

 

 

Streptomycin is neurotoxic and may affect the VIII cranial nerve (especially vestibular related) causing nausea, vomiting, vertigo and deafness. The incidence of these side effects, which is greater in elderly patients or patients with renal insufficiency, is proportional to the duration of the treatment and the total dosage administered. In cases of renal insufficiency the dose should be reduced proportionally. The neurotoxicity of streptomycin can result in respiratory paralysis from neuromuscular blockade, especially when the medication is administered concomitantly, immediately after the use of anesthesia or concomitantly with muscle relaxants.

 

Since streptomycin readily crosses the placental barrier, caution in use of the drug is important to prevent ototoxicity in the fetus. It is also excreted in small amounts in human breast milk.

 

None known.

 

The concurrent or sequential use of other neurotoxic or nephrotoxic medications with streptomycin, including neomycin, kanamycin, gentamicin, tobramycin, amikacin, netilmicin, cephalodrine, paromomycin, viomycin, polymyxin B, colistin, vancomycin, etc. should be avoided. Streptomycin should not be administered concomitantly or immediately after the use of anesthesia or curare or muscle relaxants.

 

Ototoxicity, paraesthesia of face, skin rash and other rare allergic manifestations which are generally benign.

 

If otologic symptoms are manifested the treatment should be discontinued. Should allergic reactions occur the treatment should be discontinued and appropriate treatment should be instituted with antihistamines, corticosteroids or adrenaline depending on its severity. In the case of an overdose or accidental ingestion, contact your local poison control center.