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What is this drug used for?
Pizotifen is used for the prevention of migraine headaches. It is not used to treat headaches once they have started. It is not known exactly how this medication works, but it is thought to affect chemicals, called neurotransmitters, in the brain.
Your doctor may have suggested this medication for conditions other than the ones listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
Is there any reason not to take this drug?
Pizotifen should not be taken by anyone who:
is allergic to pizotifen or any of the ingredients of the medication
is taking monoamine oxidase (MAO) inhibitors
is under the age of 12 years
has a pyloroduodenal obstruction or stenosing pyloric ulcer
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What about possible side effects?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
More common:
drowsiness
increased appetite
weight gain
Less common or rare:
abdominal discomfort
confusion
depression
dizziness
dry mouth
edema (fluid retention)
fatigue
headache
impotence
low blood pressure
muscle pain
nausea
nervousness
weakness
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
What if I am taking other drugs?
There may be an interaction between pizotifen and any of the following:
alcohol
barbiturates (e.g., phenobarbital, butalbital)
benzodiazepines (e.g., diazepam, lorazepam)
diabetes medications
heart disease medications
sedatives
sleeping pills
tricyclic antidepressants (e.g., amitriptyline, desipramine)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
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Other information:
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Drowsiness/reduced alertness: Drowsiness may occur with use of pizotifen and this may impair your ability to drive or operate machinery. Exercise caution with these activities until you find out whether the medication affects you in this way.
Medical conditions: People with narrow-angle glaucoma or with urinary retention (e.g., enlarged prostate) must excercise caution if using this medication. In general, people with narrow-angle glaucoma should not take pizotifen unless it is required and they are under special care and medical supervision for this condition. People with diabetes, heart disease, or known or suspected impaired kidney or liver function should take pizotifen with caution.
Tolerance: With prolonged use of pizotifen, some people find that it no longer works successfully. If this happens, contact your doctor.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Special Instructions:
The dose of pizotifen is usually started low (0.5 mg at bedtime) and increased gradually to 0.5 mg 3 times daily. The average maintenance dose is 1.5 mg per day. The dose range is 1 mg to 6 mg daily depending on the response to the medication. The goal is to reach the lowest dose that best prevents migraine headaches without causing significant side effects. It may take up to 4 weeks for the medication to have its maximum effect.
Your doctor may have you gradually reduce your dosage after having success with it to determine if you still need the medication. Your dose will be reduced gradually to prevent a "rebound" headache. If your headaches return after you have stopped taking the medication, your doctor may prescribe pizotifen again.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
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