Information: Nolotil, Metamizol

Nolotil 575mg
Metamizol


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PHARMACOKINETICS:
It is quickly and completely absorbed in the digestive tract, metabolized in the liver to various metabolites, and only 3% of the administered dose is excreted unchanged through the kidneys. Its half-time in the blood is about 2.7 h.
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INDICATIONS:
Acute and chronic pain accompanying the following diseases: rheumatoid arthritis, headache, toothache,traumas, dysmenorrhea and surgical intervention, strong pain associated with smooth muscles spasms of the gastrointestinal tract, biliary ducts and urogenical system, and for reducing the body temperature in febrile states.
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CONTRAINDICATIONS:
Nolotil must not be administered to patients with hypersensitivity to pyrazolone derivatives, some metabolic diseases (hepatic porphyria and comgenital deficit of glucose-6-phosphate dehyrogenase). Its administration is contraindicated during the first three months and the last 6 weeks of pregnancy, as well as to children with a body weight below 5 kg.
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SIDE EFFECTS:
The main side effects are due to the development of hypersensitivity to the drug, the most important being shock and changes in the blood count (agranulocytosis, leukopenia and thrombocytopenia). Transitory disfunctions accompanied by oliguria, polyuria, proteinuria and intestinal nephritis can originate in patients suffering from renal diseases or after the administration of high doses. Urticarial rashes and itching on the skin, mucosa and conjuctiva can rarely be observed. Asthmatic paroxysms can be provoked in patients suffering from asthma.
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PRECAUTIONS:
The existence of hypersensitivity of the patient to the drug must be checked prior to Nolotil treatment. Blood pressure must be checked during parental administration, particularly in patients with circulatory instability and systolic arterial pressure under 100mg/ Hg.
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DRUG INTERACTIONS:
The cyclosporine level in the blood plasma is reduced during parallel administration of Nolotil and cyclosporine. Nolotil and alcohol have a reciprocal effect as regards their basic effects.
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DOSAGE AND ADMINISTRATION:
Orally to adults - 1 tablet, 1-3 times daily. It is not recommended to children.
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STORAGE:
At moderate temperature (15-30° C), in a place protected from light.

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