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XICIL® Glucosamine sulphate
COMPOSITION
Each sachet contains: 1884 mg. crystalline glucosamine sulphate (INN) (equivalent to 1500 mg. glucosamine sulphate); Aspartame, (E 951); Sorbitol; Polyethylenglycol 4000; Citric acid.
PHARMACEUTICAL FORM AND CONTENTS OF THE PACKAGE
Powder for oral solution. Packs with 20 or 30 single-dose sachets, each containing 1500 mg. Glucosamine Sulphate.
ACTIVITY
Arthrosis is a degenerative process that takes place in the articular cartilage due to anomalies in the synthesis of proteoglycans by chondrocytes.
Glucosamine sulphate, the active ingredient of Xicil, is a molecular synthesis. Glucosamine is a substance which is naturally present in the human body and is the primary substrate for the biosynthesis of proteoglycans. Glucosamine sulphate has also been shown to inhibit the activity of some cartilage-destroying enzymes and other tissue-damaging substances such as superoxide radicals.
The glucosamine content in Xicil relieves the symptoms and delays the progression of the arthrosis process.
INDICATIONS
Xicil, glucosamine sulphate, is indicated for the treatment of arthrosis of large and small joints, such as spinal column, hip, knee, hand, etc….
CONTRAINDICATIONS
Xicil should not be administered to patients with hypersensitivity to glucosamine sulphate or to any other of its ingredients.
PRECAUTIONS
None known.
INTERACTIONS
The oral administration of glucosamine sulphate enhances the gastrointestinal absorption of tetracyclines. The oral administration of Xicil decreases the gastrointestinal absorption of penicillin and chloramphenicol. There is no interaction when administered concomitantly with piroxicam.
WARNINGS
Warnings about excipients
The powder for oral solution contains the excipient Aspartame. Patients with phenylketonuria should take into account that each sachet contains 1,4 mg. of phenylalanine. This medication contains 2,0285 gr. of the excipient Sorbitol per sachet. It may cause upset stomach and diarrhoea. It should not be taken by patients with hereditary fructose intolerance.
Pregnancy and lactation
Since there are no studies of the use of glucosamine sulphate during human pregnancy or lactation, the administration of this medication should be avoided during these periods.
Effects on ability to drive and use machines
Xicil is not known to impair the ability to drive or use machines.
POSOLOGY
The recommended dose is one single-dose sachet per day, which contains 1.500 mg. glucosamine sulphate, for periods of 4 to 12 weeks. In order to maintain its therapeutic activity, treatment should be repeated at 2 month intervals.
INSTRUCTIONS FOR THE CORRECT ADMINISTRATION OF THIS MEDICATION
Pour the contents of one sachet in half a glass of water; mix until dissolved and drink straight away. It is recommended that the medication be taken before meals.
OVERDOSE
No cases of accidental or intentional overdose are known.
ADVERSE EFFECTS
The side effects of Xicil are not frequent and are usually transient and of minor severity. On rare occasions nausea, gastric discomfort and pain, meteorism, constipation, diarrhoea, dizziness, somnolence and headache have been reported.
Hypersensitivity reactions.- The occurrence of erythema, pruritus or bronchial asthma is rare. Treatment should be suspended if any allergic type reaction occurs.
If you notice any other reaction not mentioned in this leaflet, please inform your doctor or pharmacist.
EXPIRY
This medication should not be used after the expiry date indicated on the pack.
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