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How does it work?
Dexketoprofen belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs).
It works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of chemicals in the body called prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause swelling, inflammation and pain.
By blocking cyclo-oxygenase, dexketoprofen prevents the production of prostaglandins and therefore reduces inflammation and pain.
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What is it used for?
Mild to moderate pain
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Warning!
This medicine may cause dizziness and so may affect your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance.
For fast relief of pain, take at least 30 minutes before food, as food delays the absorption of this medicine from the gut.
This medicine is not for long term use
Use with caution in
Decreased heart function
Disorders involving the formation of blood cells (haematopoietic disorders)
Elderly people
Excess retention of water in the body tissues (fluid retention)
History of allergies
Long-term inflammation of skin and some internal organs (systemic lupus erythematosus)
Low volume of circulating blood (hypovolaemia)
Mild to moderately decreased liver function
Mildly decreased kidney function
Syndrome with symptoms of systemic lupus erythematosus, scleroderma, polymyositis, and raynaud's phenomenon (mixed connective tissue disease)
Not to be used in
Active bleeding
Allergy to aspirin or other medicines in this class (NSAIDs)
Asthma or history of asthma
Bleeding disorders
Bleeding from the stomach or intestines
Breastfeeding
Children
Crohn's disease
History of stomach or duodenal ulcers or indigestion
Inflammation of the bowel and back passage (ulcerative colitis)
Inherited tendency to bleed (haemorrhagic diathesis)
Moderate to severely decreased kidney function
Peptic ulcers
Pregnancy
Severe heart failure
Severely decreased liver function
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
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Pregnancy and Breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
The manufacturer states not to use this medicine during pregnancy and breastfeeding as there is insufficient safety information available. Seek medical advice from your doctor.
Label warnings
Take this medication half to one hour before food.
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Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Headache
Swelling of the legs and ankles due to excess fluid retention (peripheral oedema)
Blood disorders
Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain
Indigestion (dyspepsia)
Ulceration of the stomach or intestine
Awareness of your heartbeat (palpitations)
Dizziness
Damage to the kidneys
An extreme allergic reaction (anaphylaxis)
Nervousness
High blood pressure (hypertension)
Narrowing of the airways (bronchospasm)
Damage to the liver
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
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How can this medicine affect other medicines?
Dexketoprofen may decrease the removal of lithium and methotrexate from the body, resulting in an increased risk of side-effects.
Dexketoprofen should not be taken with blood thinning or anti-clotting medicines such as warfarin, as this may increase the risk of bleeding.
Dexketoprofen may enhance the effect of some antidiabetic medicines, which could lead to low blood sugar levels.
Dexketoprofen may decrease the effects of blood pressure lowering medicines such as diuretics and beta-blockers.
When taken with cyclosporin or tacrolimus, diuretics such as frusemide or ACE inhibitors such as enalapril, there may be an increased risk of kidney damage. Kidney function should be monitored in these cases.
When taken with any other NSAIDs there may be an increased risk of side effects.
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